ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Abstract Background We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril.Methods Thickening of the aortic valve leaflets in